Phenylalanine Hydroxylase, Tyrosine Hydroxylase, and Tryptophan Hydroxylase
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چکیده
منابع مشابه
Inherited disorders affecting dopamine and serotonin: critical neurotransmitters derived from aromatic amino acids.
Many inherited disorders affecting aromatic amino acid metabolism have been described. This review will concentrate on the defects that lead to deficiencies of dopamine and serotonin within the central nervous system. Phenylalanine hydroxylase, tyrosine hydroxylase, and tryptophan hydroxylase all require tetrahydrobiopterin (BH4) as a cofactor. Inherited defects that reduce the concentration of...
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A selection procedure was devised for neurons and related cells that depends upon the ability of the cells to synthesize certain amine neurotransmitters. The rationale for selection is that tyrosine is an essential amino acid for most mammalian cells and that three enzymes from mammalian sources can catalyze the synthesis of tyrosine: phenylalanine hydroxylase (EC 1.14.16.1), tyrosine hydroxyla...
متن کاملPhenylketonuric Tetrahymena: phenylalanine hydroxylase mutants and other tyrosine auxotrophs.
Nineteen tyrosine auxotrophs of the ciliated protozoan Tetrahymena thermophila have been isolated and biochemically examined. These mutants are defective in the conversion of phenylalanine to tyrosine; this is analogous to the defect that causes phenylketonuria in humans. After nitrosoguanidine mutagenesis and self-fertilization, progeny clones were screened for tyrosine auxotrophy and positive...
متن کاملTryptophan hydroxylase activity in brain slices.
Numerous experimental data have shown that the rate of 5-hydroxytryptamine (5-HT) synthesis is enhanced by neuronal activity in mammalian central 5-HT neurons (Hamon and Glowinski, 1974; Knapp et al., 1975; Neckers et al., 1977; Boadle-Biber et al., 1983). The change of 5-HT synthesis may be due to rapid and reversible modifications of the activity of tryptophan hydroxylase (EC 1.14.16.4), whic...
متن کاملMutation analysis of Phenylalanine hydroxylase gene in Iranian patients with Phenylketonuria
Background: Phenylketonuria as the most common genetic metabolic disorder is the result of disruption of the phenylalanine hydroxylase gene. This study was carried out to explore the phenylalanine hydroxylase gene mutation status of Iranian phenylketonuria patients. Methods: Blood samples were collected from 30 patients, and hot spot areas of the phenylalanine hydroxylase gene, in...
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